Tuning Chromosomal Instability to Optimize Tumor Fitness
نویسندگان
چکیده
منابع مشابه
Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution.
Large-scale, massively parallel sequencing of human cancer samples has revealed tremendous genetic heterogeneity within individual tumors. Indeed, tumors are composed of an admixture of diverse subpopulations-subclones-that vary in space and time. Here, we discuss a principal driver of clonal diversification in cancer known as chromosomal instability (CIN), which complements other modes of gene...
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Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity. A major question of cancer gene...
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The discovery of a stem cell population in human neoplasias has given a new impulse to the study of the origins of cancer. The tissue compartment in which transformation first occurs likely comprises stem cells, since these cells need to consolidate the short-term and long-term requisites of tissue renewal. Because of their unique role, stem cells have a combination of characteristics that make...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2017
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-16-1415